It Was All About the Video! (Powerlineblog)

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Kremlin backer resigns seat, Russia opposition sees ploy

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Waiakea Recreation Center to Close For Renovation | Big Island Now

The Waiakea Recreation Center in Hilo will close Monday for a million-dollar renovation project.

The center?s tatami mats will be moved to the Pi`ihonua Gym at Gilbert Carvalho Park where martial arts, fitness programs and other center functions will be held during the renovation. To accommodate that move, the Pi`ihonua Gym will be closed beginning Monday and reopen on Nov. 5.

The work will include replacing the lower roof and structure and modifying the building to meet the requirements of the Americans with Disabilities Act, said Jason Armstrong, spokesman for the county Department of Parks and Recreation.

The renovation is scheduled to be completed in mid-March, Armstrong said.

Stan?s Contracting submitted the winning bid of $1.07 million for those and related renovations to the facility.

The center?s Quonset hut and boxing-training room will remain open during most of the construction phase, closing only briefly for safety reasons, he said. The center?s parking lot will not be available for most of the work so people utilizing those facilities should use on-street parking.

Only the Kuawa Street driveway access will remain open the renovation, Armstrong said.

For information about Waiakea Recreation Center programs call Recreation Director John Kushi at 936-4721.

Source: http://bigislandnow.com/2012/10/18/waiakea-recreation-center-to-close-for-renovation/

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U.S. Government Has Little Authority to Stop Unsafe Cosmetics

Under federal law, cosmetics companies don't have to disclose chemicals or gain approval for the 2,000 products that go on the market every year. Image: Flickr/J?rg Weingrill

Hair stylist Natalija Josimov combed the straightening solution through her client's hair. She snapped on the blow dryer, and the heated hair sent up a plume of white vapor that wrapped them in a toxic cloud. Next came the 450-degree flat iron, letting loose another sharp stink of embalming fluid that burned her eyes and made her nauseous.

Every day for months, Josimov performed three or four chemical straightening treatments at a New York City salon until she fell so ill she couldn?t even stay in the same room.

Josimov is accustomed to odors of peroxide, nail polish and permanent wave solution.?But this is different: It?s Brazilian Blowout, and its secret ingredient is formaldehyde, a carcinogen linked to nose and throat cancers, leukemia, respiratory problems and other health effects.

Brazilian Blowout is a dramatic example of how little authority federal and state governments have over the estimated $30-billion annual cosmetics industry ? even when there is compelling evidence that ingredients are dangerous.

Under federal law, cosmetics companies don't have to disclose chemicals or gain approval for the 2,000 products that go on the market every year. And removing a cosmetic from sale takes a battle in federal court.

?I thought this wouldn't be on the market if it was dangerous. I really didn't understand there was no protection,? said Josimov, who is among thousands of stylists who are pleading with government regulators to take Brazilian Blowout and similar products out of their salons and off the market.

Brazilian Blowout's Acai and Original hair-smoothing products contain high concentrations of methylene glycol, the liquid form of formaldehyde, according to government testing. The chemical helps alter the protein structure of hair strands so that they remain smooth and straight for months.

Despite a series of federal and state efforts in recent months to get rid of the product, it remains in salons across the country. The Food and Drug Administration has not prohibited it, and, without the federal government's lead, no state can easily get it off the market.

GIB LLC, the North Hollywood, Calif., company that manufactures Brazilian Blowout, was cited?last year by FDA for ?adulteration? and ?misbranding? of its Acai solution.

Another federal agency, the Occupational Safety and Health Administration, issued a health alert about formaldehyde in hair straighteners, and fined some salons where the air violated workplace safety limits. Several states, including California and New York, also have issued health alerts to stylists.

In January, the California Attorney General won a settlement against GIB for deceptive advertising and failure to disclose a known cancer-causing ingredient. And a review panel?of health experts, established by the cosmetics industry, called the hair-smoothing products "unsafe."

Representatives of GIB LLC did not grant interviews for this story despite repeated attempts to contact them. In court documents, the company called California's enforcement action ?baseless litigation? that has not proven irreparable harm to stylists.

The Food, Drug and Cosmetic Act, enacted in 1938, doesn't require FDA approval before a beauty product is sold to the public or give the agency authority to recall a harmful product, according to Michael Landa, director of the FDA's Food Safety and Applied Nutrition branch, who testified at a congressional subcommittee earlier this year.

Michael DiBartolomeis, chief of the safe cosmetics program at the California Department of Public Health, said Brazilian Blowout is an example of a product that never should have gone on the market.

Source: http://rss.sciam.com/click.phdo?i=6643e0340ecbe8195fec7594b59f579e

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Home resales slip, housing recovery still eyed

WASHINGTON (Reuters) - Home resales retreated in September from a two-year high, a reminder that America's housing sector is a long way from a full recovery despite recent signs of improvement.

The National Association of Realtors said on Friday that existing home sales dropped a modest 1.7 percent last month to a seasonally adjusted annual rate of 4.75 million units, matching the median forecast in a Reuters poll.

Housing has been a relative bright spot in the U.S. economy this year, and Friday's data did not point to a reversal in that trend. The reading for August was revised slightly higher to show resales at a 4.83 million-unit annual rate.

"While these numbers bounce around, there is no doubt that this is showing the housing market is improving," said Joel Naroff, president of Naroff Economic Advisors in Holland, Pennsylvania.

Nationwide, the median price for a home resale was $183,900 in September, up 11.3 percent from a year earlier as fewer people sold their homes under distressed conditions compared to a year earlier. Distressed sales include foreclosures.

U.S. stocks opened lower on Friday following disappointing results from Microsoft and McDonald's, while prices on U.S. treasuries edged higher.

America's economy has shown signs of faster growth in recent months as the jobless rate has fallen and retail sales data has pointed to stronger consumer spending.

The nation's inventory of homes - those for sale on the market - fell 3.3 percent during the month to 2.32 million.

At the current pace of sales, inventories would be exhausted in 5.9 months, the lowest rate since March 2006, the NAR said.

Lawrence Yun, an economist at the NAR, said the low level of inventories was partially due to a lack of new homes. With inventories of new homes still weak - groundbreaking on new homes remains 60 percent below its 2006 peak - sales are more concentrated in the market for existing homes.

Still, home building could add to economic growth this year for the first time since 2005. Existing home sales also help growth, as people furnish the homes they buy and realtors charge commissions.

This week, Goldman Sachs estimated growth in the housing sector will likely add about a quarter percentage point to economic growth this year and could add a half point in 2013.

In a bid to help the economy by encouraging people to buy homes, the Fed said last month it would buy $40 billion in mortgage-backed securities every month until the jobs outlook improves substantially.

The Fed's efforts to lower borrowing costs have pushed interest rates on 30-year mortgages to all-time lows.

In September, distressed sales fell to 24 percent of total sales from 30 percent a year ago.

Still, the share of distressed sales, which also include those where the sales price was below the amount owed on the home, increased in September of this year from 22 percent in August.

(Additional reporting by Richard Leong in New York; Editing by Neil Stempleman)

Source: http://news.yahoo.com/u-existing-home-sales-fall-inventories-drop-140027822--business.html

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Sony Xperia T now available from Vodafone UK

Following recent announcements from fellow UK carriers, Three and O2, Vodafone has made their own announcement regarding the Sony Xperia T. The latest high-end offering from Sony is now available from the carrier for free, on their Red price plans starting at £37 per month. For that, you'll get unlimited minutes and messaging, 1GB of data and 2GB of BTOpenZone WiFi access. 

At this price, Vodafone is slightly more expensive than competing networks, in particular Three. In any case, if you've been waiting for an Xperia T to hit Vodafone, now's your chance. Let us know in the comments below if you're thinking of picking one up. The full presser can be found after the break.

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Source: http://feedproxy.google.com/~r/androidcentral/~3/QXPQ1WyASKM/story01.htm

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Trojan horse drug therapy provides new approach to treating breast cancer

Public release date: 2-Oct-2012
[ | E-mail | Share ]

Contact: Katie Neal
nealkc@wfu.edu
336-758-6141
Wake Forest University

Administrative assistant inspires Wake Forest chemistry researchers

When Linda Tuttle was diagnosed with breast cancer, she never imagined her experience would inspire her colleagues to design new treatments to tackle the disease.

An administrative assistant in the Department of Chemistry at Wake Forest University, Tuttle was more accustomed to talking to faculty and staff about meetings and course loads not doctors' appointments and treatment plans.

But after her 2009 diagnosis, Tuttle's use of tamoxifen, a drug commonly used to treat breast cancer, inspired medicinal chemist Ulrich Bierbach to develop a targeted therapy that delivers a sneak attack to the disease, similar to a Trojan horse.

Trojan horses and targeted warheads

Current platinum-based drugs, such as the blockbuster drug cisplatin, do not work on the most common and most difficult-to-cure types of cancer, including lung and breast.

Building upon more than a decade's work in platinum-based drug research, Bierbach's team now designs synthetic hybrid molecules that more effectively tackle otherwise chemo-resistant cancers, including breast cancer. Results of this work, funded by the National Cancer Institute at the National Institutes of Health, appear in the September 13 issue of the Journal of Medicinal Chemistry.

Results also have led to tumor-seeking magic bullets that attach platinum to endoxifen, a close relative of tamoxifen, and quietly hitch a ride to the diseased cells, as if hidden in a Trojan horse.

"Platinum-based drugs cause severe damage to the DNA in cancer cells. Unfortunately, most cancers are smart enough to cut out the DNA damage and repair it, and that's the starting point for our structural design. We developed a compound that does a good job therapeutically by overwhelming the 'damage repair police' of the cell," said Bierbach, a chemistry professor who recently completed a four-year term with the California Breast Cancer Research Program.

Bierbach said that instead of killing certain cancer cells, cisplatin causes kinks in the DNA strand, which prompt cell enzymes to repair the damage. Wake Forest's new platinum-based molecule has a much higher affinity for DNA than cisplatin and twists it in a way that is not easily identified by the cancerous cell.

Initial preclinical studies have proven Bierbach's army of molecules to be 500 times more powerful than cisplatin in treating non-small cell lung cancer, 80-100 times for pancreatic cancer and up to 10 times for breast cancer.

"Within the next two years, we hope to turn our platinum-based drugs into safer, targeted warheads by attaching them to vehicles that will take them to a specific type of cancer and act as a guided missile," he said.

Hope on the horizon

Offering a safer way of delivery will be an important step in convincing industrial partners and the Food and Drug Administration (FDA) to move forward with clinical testing, which Bierbach estimates could be another three to four years away. Still, he and Tuttle remain encouraged given the progress to date.

For nearly three years, they met several times a week to explore Tuttle's treatment options, discuss possible side effects, and defuse her fears.

"My grandmother had breast cancer. We were even the same age when we were diagnosed," said Tuttle. "Now every time I have a strange pain or a headache, I can't help but wonder if I have another tumor."

But unlike her grandmother, whose late stage breast cancer metastasized, Tuttle's cancer was only stage 1 when a routine mammogram detected it. Today she is in remission following a lumpectomy and radiation therapy, and her quality of life has improved.

Though her prognosis looks promising, she and Bierbach still get together frequently in the halls of the chemistry department to share stories hers of how she now lives every day to its fullest, and his of the lab's progress with its challenging research projects.

"Our professional relationship has definitely grown," said Tuttle. "I hope his research group stays as focused as it is now. Every advancement helps."

"Wake Forest's motto is Pro Humanitate, which means 'for humanity,' and it motivates our research group daily," Bierbach added. "Everyone knows someone who has been affected by cancer, and there's a pressing need for more effective and less toxic chemotherapies. The solution starts with some combination of academic curiosity and personal experience, and takes place in a lab that has synthetic chemistry expertise and a good deal of imagination to think about new ways to tackle cancer mechanistically at the molecular level. It's a fulfilling job, but it's even more rewarding to help someone you know."

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 2-Oct-2012
[ | E-mail | Share ]

Contact: Katie Neal
nealkc@wfu.edu
336-758-6141
Wake Forest University

Administrative assistant inspires Wake Forest chemistry researchers

When Linda Tuttle was diagnosed with breast cancer, she never imagined her experience would inspire her colleagues to design new treatments to tackle the disease.

An administrative assistant in the Department of Chemistry at Wake Forest University, Tuttle was more accustomed to talking to faculty and staff about meetings and course loads not doctors' appointments and treatment plans.

But after her 2009 diagnosis, Tuttle's use of tamoxifen, a drug commonly used to treat breast cancer, inspired medicinal chemist Ulrich Bierbach to develop a targeted therapy that delivers a sneak attack to the disease, similar to a Trojan horse.

Trojan horses and targeted warheads

Current platinum-based drugs, such as the blockbuster drug cisplatin, do not work on the most common and most difficult-to-cure types of cancer, including lung and breast.

Building upon more than a decade's work in platinum-based drug research, Bierbach's team now designs synthetic hybrid molecules that more effectively tackle otherwise chemo-resistant cancers, including breast cancer. Results of this work, funded by the National Cancer Institute at the National Institutes of Health, appear in the September 13 issue of the Journal of Medicinal Chemistry.

Results also have led to tumor-seeking magic bullets that attach platinum to endoxifen, a close relative of tamoxifen, and quietly hitch a ride to the diseased cells, as if hidden in a Trojan horse.

"Platinum-based drugs cause severe damage to the DNA in cancer cells. Unfortunately, most cancers are smart enough to cut out the DNA damage and repair it, and that's the starting point for our structural design. We developed a compound that does a good job therapeutically by overwhelming the 'damage repair police' of the cell," said Bierbach, a chemistry professor who recently completed a four-year term with the California Breast Cancer Research Program.

Bierbach said that instead of killing certain cancer cells, cisplatin causes kinks in the DNA strand, which prompt cell enzymes to repair the damage. Wake Forest's new platinum-based molecule has a much higher affinity for DNA than cisplatin and twists it in a way that is not easily identified by the cancerous cell.

Initial preclinical studies have proven Bierbach's army of molecules to be 500 times more powerful than cisplatin in treating non-small cell lung cancer, 80-100 times for pancreatic cancer and up to 10 times for breast cancer.

"Within the next two years, we hope to turn our platinum-based drugs into safer, targeted warheads by attaching them to vehicles that will take them to a specific type of cancer and act as a guided missile," he said.

Hope on the horizon

Offering a safer way of delivery will be an important step in convincing industrial partners and the Food and Drug Administration (FDA) to move forward with clinical testing, which Bierbach estimates could be another three to four years away. Still, he and Tuttle remain encouraged given the progress to date.

For nearly three years, they met several times a week to explore Tuttle's treatment options, discuss possible side effects, and defuse her fears.

"My grandmother had breast cancer. We were even the same age when we were diagnosed," said Tuttle. "Now every time I have a strange pain or a headache, I can't help but wonder if I have another tumor."

But unlike her grandmother, whose late stage breast cancer metastasized, Tuttle's cancer was only stage 1 when a routine mammogram detected it. Today she is in remission following a lumpectomy and radiation therapy, and her quality of life has improved.

Though her prognosis looks promising, she and Bierbach still get together frequently in the halls of the chemistry department to share stories hers of how she now lives every day to its fullest, and his of the lab's progress with its challenging research projects.

"Our professional relationship has definitely grown," said Tuttle. "I hope his research group stays as focused as it is now. Every advancement helps."

"Wake Forest's motto is Pro Humanitate, which means 'for humanity,' and it motivates our research group daily," Bierbach added. "Everyone knows someone who has been affected by cancer, and there's a pressing need for more effective and less toxic chemotherapies. The solution starts with some combination of academic curiosity and personal experience, and takes place in a lab that has synthetic chemistry expertise and a good deal of imagination to think about new ways to tackle cancer mechanistically at the molecular level. It's a fulfilling job, but it's even more rewarding to help someone you know."

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-10/wfu-thd092812.php

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Rad Linc Crafts: Oh Baby! Hosting a Baby Shower

Hosting a baby shower kinda reminded us of planning for the wedding. ?There was tons to do and great reasons to try things that I've never tried before, and there was fun to be had. :)

As any sister might want, I wanted my sister's baby shower to be spectacular, because she's awesome and deserves nothing less. Unfortunately, there was a lot for me to learn since I'm not really what people would consider a "baby" person. ?Which is why I'm grateful for the help of great friends and family who helped with many aspects of the baby shower to make it spectacular. ?I could not have done it without them.

Anyway, I thought I'd share some things from my sister's dragon themed baby shower.

First were the invitations. ?I decided to go with one of the many diaper invitations that I've seen on the interwebs. ?I really didn't want to cut each one individually however, because there were going to be 60 invites created (we have a large extended family). ?So, I used blue card stock, drew the design on the top of a stack of them, taped the whole stack together with some masking tape, and used my scrollsaw to cut them all. ?A few things I learned from this:
1. ?I really need to practice straight lines with my scroll saw (sigh).
2. ?Be ready to assume that the top and bottom card stock will be ruined. ?So whatever number of cuts you want, add 2.
3. ?If you're really good (which I'm not, but maybe with more practice), this is an awesome way to cut a ton of paper to a design in one shot (can we say Christmas cards?).

The front of the cards had slits so that the tabs folded into them, closing up the diaper into a neat little package. ?We added the buttons and the ribbon, and my personal favorite, the dragon tail (attached via a brad, so it swung a little).

In the inside of the card, we glued (tip: use stick glue, not craft glue) a printout of the shower information. ? I don't have a picture of the envelop, but it had a cool castle printed onto them to add to the theme.

Next, I found some examples of fill-in cards online, and replicated them for motherly advice and wishes for the new prince. ?We had a book donation (listed in the invite), with a raffle. ?Each book received got a raffle ticket and we called the raffle number afterwards for a fun prize. ?The two castles serving as book ends were two wooden bird houses (bought from Michaels), painted and with bags of aquarium rocks inside for weight (we'll figure out something better later). ?I created feather quills (pens) for people to use to fill up the fill-in cards and the book donation removable labels. ?Aside from the fill-in cards and book donation/raffle, one of the popular games we played was Gift Bingo?(cards made by Emily).
Some of the decorations for the party.
1. ?A cupcake tower of diaper favors. ?We folded and pinned small squares of fabric into diapers, wrapped some jordan almonds or mints into a bit of tulle, and stuck it inside the diapers.
2. ?A coat of arms researched and created by my talented husband which has the phrase "Consilio Et Animis" meaning "By wisdom and Courage."
3. ?A diaper castle that I built with a working drawbridge. I used wipes packages for the fillers inside, a couple of bottles to hold the book roof up, a sewn receiving blanket for the base, and some washcloths to cover the cardboard drawbridge.
4. ?Some really awesome soft fabric blocks made by Emily, my sister's BFF.
5. ?We also used all the onesies for the onesie decorating activity for more decorations (see them hanging in the background).
6. ?There were also a lot of balloons and crepe paper, and some store bought puffs, and a yard sign (and probably other things I'm forgetting).
One of the many new things I learned during this experience was learning to work with fondant. To me fondant is kinda like working with clay. ?You can use tools to shape things and you can use a dab of water to put them together (not that you'd need to do that with clay). I found these year of the dragon cupcake toppers on a pinterest post. ?The tutorial was perfect. ?I made the dragon toppers a few days ahead of time and let them air dry. ?We ordered a plain cake from Vons with the words "Welcome Baby" printed on, and before the party, we positioned the toppers right in. :)
One of the fun activities that we did for the shower were decorating onesies. ?For this, we needed a lot of onesies (tip: get varying sizes (0-18m) so that the baby can use them for the year), fabric with Heat'n Bond Lite Iron-on Adhesive?already on the back (ready to be ironed onto the onesie), lots of stencils for designs, fabric pens, cardboard (so pens don't bleed to the other side of the onesie), an iron and ironing board. ?We bought a cheap clothesline and hung the onesies up with some wooden clothespins (that my sister glued fabric yo-yos to). ?There were a lot of really creative onesie designs. ?The cutie pi one was mine. :)
Lastly, we had a Baby Jeopardy competition. ?Here's the board the Emily made. ?Everyone had a blast with that game.

Hopefully these have helped you gain some ideas for any baby shower you happen to host in the future.

Source: http://radlinccrafts.blogspot.com/2012/09/oh-baby-hosting-baby-shower.html

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